- Description
Specifications
Description:
Genizer Multi Online Liposome Extruders System can be connected with a sanitary pump or high pressure homogenizer and are temperature-controlled, from pilot testing to manufacturing production of pharmaceutical liposomes such as anti-cancer drugs. Homogenous samples can be produced quickly and easily in minutes; typically 3-5 passes are sufficient to produce a sample with uniform liposome size. The Genizer Multi Online Liposome Extruders System is designed to generate homogeneous unilamellar liposomes and lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The Multi Online Extruders System offers minimal dead volume, is easy to clean, suitable for sterilization and compliant with FDA and GMP sanitary standards in pharmaceuticals.
Application:
Liposome extrusion
Performance:
Minimal dead volume
The Multi Online Extruders System can control the temperature of the extrusion while producing up to 200L yield of liposome per batch.
The Multi Online Extruders System can control the temperature of the extrusion while producing up to 200L yield of liposome per batch.
Specifications | ||||||
Catalog No. | GOE-8L-2 | GOE-8L-4 | GOE-8L-6 | GOE-8L-8 | GOE-20L-4 | |
Sample Size | 10L-20L | 20L-40L | 40L-60L | 60L-80L | 80L-100L | |
Cooling | Jacketed | Jacketed | Jacketed | Jacketed | Jacketed | |
Dimensions | 30cm×25cm×25cm | 30cm×25cm×25cm | 30cm×25cm×25cm | 30cm×25cm×25cm | 45cm×40cm×30cm | |
Weight | 70kg | 120kg | 170kg | 220kg | 400kg | |
Min. Sample Size | 1L | 2L | 4L | 6L | 8L | |
Application | Liposome formulation up to production scale | |||||
Max. Pressure | 1,000 psi-5,000 psi | |||||
Temp. Limit | 80ºC (176ºF) | |||||
Power Type | High pressure pump or high pressure homogenizer | |||||
Nano-membrane | Track-etched membrane | |||||
Cleaning | Flush to clean/CIP/SIP | |||||
Sterilization | Whole unit autoclavable | |||||
Standard Features | ||||||
Parts | 1) Liposome Online Extruder 2) 10 pieces of 100nm membrane (sample pack) |
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Filter Support | Jacketed filter support with pagoda inlet and outlet | |||||
Inlet Type | 3/8" high pressure coupling | |||||
Outlet Type | 3/8" high pressure coupling | |||||
Handle | Handle for GOE-8L and GOE-20L | |||||
Nano Membrane | 100nm track-etched polycarbonate membrane | |||||
Compatibility | Some Parts are compatible with high pressure fittings | |||||
Product Material | 316L stainless steel, viton | |||||
Material Standard | Sanitary grade; compliant with FDA and GMP sanitary standards | |||||
Warranty | 1 year against any manufacturing defects | |||||
Option Features | ||||||
Detector | 10,000psi sanitary pressure gauge with adaptor, pressure transducer, temperature transducer | |||||
Control System | Tradition mechanical control: speed, start, stop controls; FDA 21CFR Compliance; Explosion-Proof | |||||
Power | Sanitary high pressure piston pump/hand pump | |||||
Inlet Type | Tri-clamp or luer lock | |||||
Outlet Type | Tri-clamp or luer lock | |||||
Nano Membrane | 30nm, 50nm, 80nm, 100nm, 200nm, 400nm, 800nm, 1000nm, 2μm, 5μm, 10μm, 20μm, 30μm track-etched membrane (Dia. 142mm, Dia. 293mm) | |||||
Multi Extruder | Parallel or series connection of multi extruder URS for Liposome Extruders System.doc |
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Product Introduction and User Guide Video Sharing: Introduction of Jacketed Liposome Extruder Introduction of HandExtruder How to make liposome with HandExtruder |